Title : [Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors].

Pub. Date : 2001 Sep

PMID : 11577463






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 [Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors]. Aspirin mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 During the century after that, aspirin has been found to show its anti-inflammatory, analgesic and anti-pyretic activities by reducing prostaglandins biosynthesis through inhibition of cyclooxygenase (COX); and then COX was found to be constituted of two isoforms, constitutive COX-1 and inducible COX-2. Aspirin mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Currently, novel NSAIDs, acting through selective inhibition of COX-2, that have efficacy as excellent as aspirin with significantly lower incidence of gastrointestinal adverse effects are available in America and some other countries, but not in Japan. Aspirin mitochondrially encoded cytochrome c oxidase II Homo sapiens