Pub. Date : 2001 Dec 14
PMID : 11577091
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have recently shown that MAPK activation and c-Fos expression are uncoupled in F9 cells upon retinoic acid-induced endodermal differentiation. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Transfection and expression of Disabled-2 in PA-1 cells mimic the effects of retinoic acid on growth suppression; the Disabled-2-expressing cells reach a much lower saturation density, and serum-stimulated c-Fos expression is greatly suppressed and disassociated from MAPK activation. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Thus, Dab2 is one of the principal genes induced by retinoic acid involved in cell growth suppression, and expression of Dab2 alone is sufficient for uncoupling of MAPK activation and c-Fos expression. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |