Title : Hexosamines and nutrient excess induce leptin production and leptin receptor activation in pancreatic islets and clonal beta-cells.

Pub. Date : 2001 Oct

PMID : 11564705






1 Functional Relationships(s)
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1 The hexosamine-mediated induction of the leptin system in clonal beta-cells was associated with increased responsiveness to leptin, as demonstrated by a 2.6 +/- 0.3-fold (P < 0.01) increase in tyrosine phosphorylation of signal transducer and activator of transcription-3. Hexosamines signal transducer and activator of transcription 3 Homo sapiens