Title : Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors.

Pub. Date : 2001 Dec 14

PMID : 11560935






1 Functional Relationships(s)
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Protein Name
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1 Analysis of chimeras and individual amino acid exchanges between Sos1 and Ras-GRF1 revealed that the critical amino acids reside within an 11-amino acid segment of their catalytic domains between the second and third structurally conserved regions (amino acids (aa) 828-838 in Sos1 and 1057-1067 in Ras-GRF1) of Ras guanine nucleotide exchange factors. Guanine Nucleotides Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens