Pub. Date : 2001 Oct
PMID : 11560871
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of CYP3A4 inhibition by diltiazem on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The aim of this study was to assess the effect of diltiazem, a CYP3A4 inhibitor, on pharmacokinetics and dynamics of diazepam in relation to CYP2C19 genotype status. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Inhibition of CYP3A4 by a concomitant substrate drug like diltiazem may cause a pharmacokinetic interaction with diazepam irrespective of CYP2C19 genotype status, but whether this interaction would reflect a pharmacodynamic change of diazepam remains unconfirmed by our study. | Diltiazem | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |