Pub. Date : 1979 Oct
PMID : 115598
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The addition of dimethylbenz[a]anthracene (DMBA), benz[a]anthracene (BA), or 3-methylcholanthrene (3-MC) to the cell culture medium increased AHH activity 5.3-, 4.7- and 2.4-fold, respectively. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | The addition of dimethylbenz[a]anthracene (DMBA), benz[a]anthracene (BA), or 3-methylcholanthrene (3-MC) to the cell culture medium increased AHH activity 5.3-, 4.7- and 2.4-fold, respectively. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | The decay of the DMBA-induced hydroxylase was biphasic: one component had a t1/2 of 15--30 min and another a t1/2 of 4 h. Norepinephrine, 17 beta-estradiol and 5,6-benzoflavone also increased AHH activity in mammary epithelial cells in vitro, however, sodium phenobarbital had no effect. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | Metyrapone and 7,8-benzoflavone, inhibitors of microsomal mixed function oxidase activity, reduced both constitutive and DMBA-induced AHH activities when added to homogenates of untreated and DMBA-treated mammary epithelial cells. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 5 | Metyrapone and 7,8-benzoflavone, inhibitors of microsomal mixed function oxidase activity, reduced both constitutive and DMBA-induced AHH activities when added to homogenates of untreated and DMBA-treated mammary epithelial cells. | 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |