Title : Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.

Pub. Date : 2001 Sep 15

PMID : 11559542






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol catechol-O-methyltransferase Homo sapiens
2 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol catechol-O-methyltransferase Homo sapiens
3 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol catechol-O-methyltransferase Homo sapiens
4 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catechol estrogens to methoxy estrogens, which simultaneously lowers the potential for DNA damage and increases the concentration of 2-methoxyestradiol (2-MeOE2), an antiproliferative metabolite. 2-Methoxyestradiol catechol-O-methyltransferase Homo sapiens