Title : CREB regulates hepatic gluconeogenesis through the coactivator PGC-1.

Pub. Date : 2001 Sep 13

PMID : 11557984






2 Functional Relationships(s)
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1 Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus
2 Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus