Pub. Date : 2001 Oct
PMID : 11557524
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate. | Taurocholic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 2 | The difference in TC transport activity between rat MRP2 and MRP3 was studied, focusing on the cationic amino acids in the transmembrane domains. | Taurocholic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |
| 3 | These results suggest that the presence of the cationic charge at Arg-586 and Arg-1096 in rat MRP2 prevents the transport of TC, whereas the presence of neutral amino acids at the corresponding position of rat MRP3 is required for the transport of substrates. | Taurocholic Acid | ATP binding cassette subfamily C member 2 | Rattus norvegicus |