Title : In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators.

Pub. Date : 2001 Aug

PMID : 11556519






1 Functional Relationships(s)
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1 In the whole blood test, aceclofenac and 4"-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively. aceclofenac mitochondrially encoded cytochrome c oxidase II Homo sapiens