Pub. Date : 2001 Apr
PMID : 11550089
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates. | polyglutamine | caspase 8 | Homo sapiens |
| 2 | We and others previously demonstrated that caspase-8 was activated by proteolysis in association with the expression of extended polyglutamine. | polyglutamine | caspase 8 | Homo sapiens |
| 3 | Caspase-8 and -10 were recruited into nuclear aggregates of extended polyglutamine, where at least a fraction of these caspases was converted to the activated forms. | polyglutamine | caspase 8 | Homo sapiens |
| 4 | Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. | polyglutamine | caspase 8 | Homo sapiens |
| 5 | Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. | polyglutamine | caspase 8 | Homo sapiens |
| 6 | Caspase-8 and -10 were co-immunoprecipitated with polyglutamine only when the polyglutamine was pathologically extended, whereas caspase-2, -3, -6, -7 and -9 were not co-immunoprecipitated with polyglutamine regardless of its size. | polyglutamine | caspase 8 | Homo sapiens |
| 7 | A dominant-negative form of caspase-8 with a mutation at the catalytic cysteine residue inhibited polyglutamine-mediated nuclear apoptotic phenotype. | polyglutamine | caspase 8 | Homo sapiens |