Title : Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis.

Pub. Date : 2001 Sep

PMID : 11546977






3 Functional Relationships(s)
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1 This has focused interest in regulation of the adrenal angiotensin II type 2 receptor (AT2) as the target thought to mediate angiotensin II-induced adrenal catecholamine release during experimental sepsis in vivo. Catecholamines angiotensinogen Rattus norvegicus
2 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines angiotensinogen Rattus norvegicus
3 Because AT2 receptors are thought to be involved in adrenal catecholamine secretion in a stimulatory fashion, the diminished expression of AT2 receptors could play an important role in the pathogenesis of septic shock via impaired angiotensin II-induced adrenal catecholamine release, despite a strong activation of the systemic renin-angiotensin system. Catecholamines angiotensinogen Rattus norvegicus