Title : Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb.

Pub. Date : 2001 Sep 15

PMID : 11535516






3 Functional Relationships(s)
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1 In one third (11 of 34) of the patients, PA antibodies showed a marked decrease (less than 50%) in reactivity with KO compared with wild-type GPIIb-IIIa. Protactinium integrin subunit alpha 2b Homo sapiens
2 The present data suggest that certain PA anti-GPIIb-IIIa autoantibodies recognize epitopes close to the ligand-binding site in GPIIb, but not in GPIIIa. Protactinium integrin subunit alpha 2b Homo sapiens
3 The present data suggest that certain PA anti-GPIIb-IIIa autoantibodies recognize epitopes close to the ligand-binding site in GPIIb, but not in GPIIIa. Protactinium integrin subunit alpha 2b Homo sapiens