Title : Interrogation of heme pocket environment of mammalian peroxidases with diatomic ligands.

Pub. Date : 2001 Sep 11

PMID : 11535049






1 Functional Relationships(s)
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1 Fe(II) forms of MPO and LPO, but not EPO, displayed significantly lower affinity toward NO compared to Fe(III) forms, suggesting that heme reduction causes a dramatic change in the heme pocket electronic environment that alters the affinity and/or accessibility of heme iron toward NO. Iron myeloperoxidase Homo sapiens