Title : Peptidoglycan primes for LPS-induced release of proinflammatory cytokines in whole human blood.

Pub. Date : 2001 Sep

PMID : 11531018






2 Functional Relationships(s)
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1 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine interleukin 6 Homo sapiens
2 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine interleukin 6 Homo sapiens