Title : An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.

Pub. Date : 2001 Sep 3

PMID : 11524436






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 This is achieved through the formation of a tricomplex consisting of Eps8-E3b1-Sos-1, which is endowed with Rac guanine nucleotide exchange activity. Guanine Nucleotides AKT serine/threonine kinase 1 Homo sapiens
2 The catalytic subunit of this complex is represented by Sos-1, a bifunctional molecule capable of catalyzing guanine nucleotide exchange on Ras and Rac. Guanine Nucleotides AKT serine/threonine kinase 1 Homo sapiens
3 In addition, it binds to Sos-1 and is able to induce Rac-specific, Sos-1-dependent guanine nucleotide exchange activity. Guanine Nucleotides AKT serine/threonine kinase 1 Homo sapiens