Title : The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation.

Pub. Date : 1975 Aug 10

PMID : 1150667






1 Functional Relationships(s)
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Protein Name
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1 The cleavage of the preactivation peptide from the NH2 terminus of native plasminogen (NH2-terminal glutamic acid) is clearly catalyzed by urokinase and is the rate-limiting first step in activation (Stage 1); this reaction is 20-fold slower than the conversion of the intermediate plasminogen (NH2-terminal lysine) to plasmin (Stage 2). Glutamic Acid plasminogen Homo sapiens