Pub. Date : 2001 Sep
PMID : 11504680
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment with 100 ng/ml of FK506 (a PP2B inhibitor) but not with the PP1 and PP2A inhibitors calyculin A or okadaic acid potentiated the thrombin-induced increase in PKC phosphotransferase activity. | Tacrolimus | coagulation factor II, thrombin | Bos taurus |
| 2 | FK506 also potentiated thrombin-induced PKC-alpha but not PKC-beta phosphorylation. | Tacrolimus | coagulation factor II, thrombin | Bos taurus |
| 3 | FK506 but not calyculin A or okadaic acid inhibited recovery from the thrombin-induced decrease in transendothelial resistance. | Tacrolimus | coagulation factor II, thrombin | Bos taurus |
| 4 | Downregulation of PKC with phorbol 12-myristate 13-acetate rescued the FK506-mediated inhibition of recovery, which was consistent with the finding that the thrombin-induced phosphorylation of PKC-alpha was reduced during the recovery phase. | Tacrolimus | coagulation factor II, thrombin | Bos taurus |