Title : Contributions of five human cytochrome P450 isoforms to the N-demethylation of clozapine in vitro at low and high concentrations.

Pub. Date : 2001 Aug

PMID : 11504269






2 Functional Relationships(s)
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1 The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4, 2C9, 2C19, and 2D6 to the N-demethylation of clozapine mediated by human liver microsomal preparations (HLM). Nitrogen cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 The authors assessed the in vitro contribution of cytochrome P450 (CYP) isoforms 1A2, 3A4, 2C9, 2C19, and 2D6 to the N-demethylation of clozapine mediated by human liver microsomal preparations (HLM). Nitrogen cytochrome P450 family 4 subfamily F member 3 Homo sapiens