Pub. Date : 2001 Sep
PMID : 11494044
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we have examined the effect of methylmethane sulfonate (MMS) to HCT-116 human colon cancer cells on the phosphorylation of p53. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 2 | In the present study, we have examined the effect of methylmethane sulfonate (MMS) to HCT-116 human colon cancer cells on the phosphorylation of p53. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 3 | Results show that p53 protein becomes phosphorylated at serine 15 (Ser15) and Ser392 residues after treatment with MMS in a time-dependent manner. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 4 | Increased levels of phospho-p53(Ser15) and phospho-p53(Ser392) were maintained up to 50 h of the MMS treatment. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 5 | Increased levels of phospho-p53(Ser15) and phospho-p53(Ser392) were maintained up to 50 h of the MMS treatment. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 6 | We also examined the involvement of probable kinase(s), which could be responsible for MMS-induced phosphorylation of p53 at Ser15 and Ser392. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 7 | In vitro phosphorylation assay, carried out with the immunoprecipates of MMS-treated cells, showed an increased phosphorylation of p53 by c-Jun kinase 1 (JNK1) at early time points (2.5 h). | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 8 | The MMS-induced phosphorylation of p53 correlates with our previous findings of p53"s ability for increased sequence-specific DNA-binding and transcriptional activity in the cells treated with DNA alkylating agents. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |
| 9 | The MMS-induced phosphorylation of p53 correlates with our previous findings of p53"s ability for increased sequence-specific DNA-binding and transcriptional activity in the cells treated with DNA alkylating agents. | Methyl Methanesulfonate | tumor protein p53 | Homo sapiens |