Pub. Date : 1975 May-Jun
PMID : 1149327
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Abolition of the renin-releasing action of frusemide by acute renal denervation in dogs. | Furosemide | renin | Canis lupus familiaris |
| 2 | The effects of infusions of frusemide at low (0.05-0.1 mg.kg-1.min-1) and high (0.5-2.0 mg.kg-1.min-1) rates were studied on renin secretion and urinary outputs of sodium and potassium in anaesthetized dogs in which one kidney was removed and the remaining kidney was either innervated or denervated. | Furosemide | renin | Canis lupus familiaris |
| 3 | High rates of infusion of frusemide caused an immediate increase in renin secretion from innervated kidneys which was not related to urinary losses. | Furosemide | renin | Canis lupus familiaris |
| 4 | Denervation of the kidney abolished the renin-releasing action of frusemide at both low and high infusion rates even when the sodium deficit amounted to 4.3 mmol.kg-1. | Furosemide | renin | Canis lupus familiaris |
| 5 | Constriction of the aorta producing a fall of 10-30 mmHg in perfusion pressure raised the rate of renin secretion from denervated kidneys to control levels and partially restored the renin-releasing action of frusemide at high infusion rates. | Furosemide | renin | Canis lupus familiaris |
| 6 | Constriction of the aorta producing a fall of 10-30 mmHg in perfusion pressure raised the rate of renin secretion from denervated kidneys to control levels and partially restored the renin-releasing action of frusemide at high infusion rates. | Furosemide | renin | Canis lupus familiaris |
| 7 | The findings indicate that frusemide has a site of action apart from the macula densa in mediating renin release. | Furosemide | renin | Canis lupus familiaris |