Pub. Date : 2001 Jun
PMID : 11491658
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation. | Disulfides | ret proto-oncogene | Homo sapiens |
| 2 | A few percentage of RET proteins normally formed disulfide-bonded dimers in the cell, and osmotic stress promoted formation of these dimers. | Disulfides | ret proto-oncogene | Homo sapiens |
| 3 | Osmotic stress also promoted activation and disulfide-bonded dimerization of the extracellular domain-depleted mutant RET (RET-PTC-1), suggesting that the target amino acid(s) for dimerization is located intracellularly rather than in the cysteine-rich region of the extracellular domain. | Disulfides | ret proto-oncogene | Homo sapiens |
| 4 | Osmotic stress also promoted activation and disulfide-bonded dimerization of the extracellular domain-depleted mutant RET (RET-PTC-1), suggesting that the target amino acid(s) for dimerization is located intracellularly rather than in the cysteine-rich region of the extracellular domain. | Disulfides | ret proto-oncogene | Homo sapiens |