Title : Tumor necrosis factor alpha-induced activation of downstream NF-kappaB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase, and IKK2, but not MAPKs, pathway.

Pub. Date : 2001 Aug

PMID : 11483407






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
2 12-O-Tetradecanoylphorbol-13-acetate (TPA), a PKC activator, stimulated ICAM-1 expression, this effect was inhibited by genistein or tyrphostin 23. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
3 TPA also stimulated NF-kappaB DNA-protein binding and ICAM-1 promoter activity, these effects being inhibited by genistein or tyrphostin 23. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
4 TNF-alpha- or TPA-induced ICAM-1 promoter activity was inhibited by dominant negative PKCalpha or IKK2, but not IKK1 mutant. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens