Pub. Date : 2001 Aug
PMID : 11477317
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The authors analyzed the importance of five CYP2D6 genotypes, *1/ *1, *1/ *10, *10/ *10, *1/*5, and *5/*10 on the percentage of change in plasma concentrations of haloperidol and reduced haloperidol. | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Patients with the CYP2D6*5 allele (n = 4) showed a significantly smaller increase in plasma concentrations of haloperidol (P < 0.05) and a slightly smaller increase in those of reduced haloperidol (P = 0.074) in response to the coadministration of chlorpromazine compared than those with the CYP2D6*1/*1 genotype (n = 8). | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Patients with the CYP2D6*5 allele (n = 4) showed a significantly smaller increase in plasma concentrations of haloperidol (P < 0.05) and a slightly smaller increase in those of reduced haloperidol (P = 0.074) in response to the coadministration of chlorpromazine compared than those with the CYP2D6*1/*1 genotype (n = 8). | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | Those with the CYP2D6*1/*1 genotype (n = 8) showed a trend toward greater increases in plasma concentrations of haloperidol than those with other genotypes (P = 0.087). | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |