Pub. Date : 2001 Jul 25
PMID : 11476896
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To understand the role of this cAMP-dependent PDE regulation in the potentiation of the mitogenic response to IGF-I, thymidine incorporation into DNA in response to IGF-I and TSH was measured in the absence or presence of PDE inhibitors. | Thymidine | insulin-like growth factor 1 | Rattus norvegicus |
| 2 | To understand the role of this cAMP-dependent PDE regulation in the potentiation of the mitogenic response to IGF-I, thymidine incorporation into DNA in response to IGF-I and TSH was measured in the absence or presence of PDE inhibitors. | Thymidine | insulin-like growth factor 1 | Rattus norvegicus |
| 3 | When IGF-I was used alone, both IBMX and RO 20-1724 potentiated IGF-I-stimulated thymidine incorporation. | Thymidine | insulin-like growth factor 1 | Rattus norvegicus |
| 4 | However, when IGF-I and TSH at high concentrations were used in combination, these PDE inhibitors blocked thymidine incorporation into DNA. | Thymidine | insulin-like growth factor 1 | Rattus norvegicus |