Title : Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Pub. Date : 2001 Aug 2

PMID : 11472217






1 Functional Relationships(s)
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1 To search for TNF-alpha (tumor necrosis factor alpha) converting enzyme (TACE) inhibitors, we designed a new class of macrocyclic hydroxamic acids by linking the P1 and P2" residues of acyclic anti-succinate-based hydroxamic acids. Succinic Acid zinc finger protein 185 Mus musculus