Title : Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.

Pub. Date : 2001 Aug

PMID : 11454912






1 Functional Relationships(s)
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1 Of 10 recombinant human P450s tested, CYP3A4 catalyzed the formation of NORCIS, 3-F-4-OHCIS, and 4-F-2-OHCIS from each enantiomer and racemic cisapride (15 microM) with the highest specific activity (Km values close to those in HLMs). 3-f-4-ohcis cytochrome P450 family 3 subfamily A member 4 Homo sapiens