Title : Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.

Pub. Date : 2001 Aug

PMID : 11454902






2 Functional Relationships(s)
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1 The activity of testosterone 6beta-hydroxylation (a selective probe for CYP3A4/5 activity) strongly correlated with the rate of formation of 2-OH-E2, 4-OH-E2, and several other hydroxyestrogen metabolites by both male and female liver microsomes. 2-hydroxyestradiol cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The activity of testosterone 6beta-hydroxylation (a selective probe for CYP3A4/5 activity) strongly correlated with the rate of formation of 2-OH-E2, 4-OH-E2, and several other hydroxyestrogen metabolites by both male and female liver microsomes. 2-hydroxyestradiol cytochrome P450 family 3 subfamily A member 4 Homo sapiens