Pub. Date : 2001 Aug
PMID : 11454723
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression. | Flavonoids | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | We examined the effects of several agents, including dietary flavonoids, on CYP1A1 expression utilizing a recently developed high-throughput screening system for assessing human cytochrome P450 (CYP) induction. | Flavonoids | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Of these flavonoids, resveratrol produced the greatest increase in CYP1A1-mediated luciferase activity (10-fold), whereas GTE, apigenin, curcumin, and kaempferol produced 2- to 3-fold increases in activity. | Flavonoids | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Cotreatment of cells with TCDD and GTE, naringenin, and apigenin resulted in 58, 77, and 74% reductions, respectively, in TCDD-mediated CYP1A1 induction, indicating that these flavonoids exhibit potential antagonist activity toward the aryl hydrocarbon (Ah) receptor. | Flavonoids | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |