Title : Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts.

Pub. Date : 2001 Jul

PMID : 11453739






1 Functional Relationships(s)
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1 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. Serine acetylcholinesterase (Cartwright blood group) Homo sapiens