Title : Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase.

Pub. Date : 2001 Jul

PMID : 11453726






2 Functional Relationships(s)
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1 Recent kinetic and mass spectral data demonstrated that a difference in mechanism of inactivation exists for AChE treated with (1R)- versus (1S,3S)-stereoisomers. Caffeine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase. Caffeine acetylcholinesterase (Cartwright blood group) Homo sapiens