Title : Spinal cord injury induced c-fos expression is reduced by p-CPA, a serotonin synthesis inhibitor. An experimental study using immunohistochemistry in the rat.

Pub. Date : 2000

PMID : 11450029






5 Functional Relationships(s)
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1 Spinal cord injury induced c-fos expression is reduced by p-CPA, a serotonin synthesis inhibitor. Serotonin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Influence of serotonin on upregulation of cellular-fos (c-fos) following a focal spinal cord injury was examined using immunohistochemistry in a rat model. Serotonin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 Influence of serotonin on upregulation of cellular-fos (c-fos) following a focal spinal cord injury was examined using immunohistochemistry in a rat model. Serotonin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
4 Pretreatment with p-CPA, a serotonin synthesis inhibitor, significantly attenuated the c-fos upregulation along with the edematous expansion of the cord. Serotonin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
5 These results for the first time suggest that trauma induced release of serotonin and edema formation are important biological signals inducing c-fos expression. Serotonin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus