Title : Glutathione homeostasis and leukotriene-induced permeability in human blood-brain barrier endothelial cells subjected to in vitro ischemia.

Pub. Date : 2000

PMID : 11450027






2 Functional Relationships(s)
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1 Sodium fluorescein clearance across HCEC monolayers exposed to leukotriene C4 in the presence of the GGTP inhibitor, acivicin (1 microM), or after in vitro ischemia was increased by 60% and 30%, respectively, suggesting that oxidative stress and loss of GGTP may "unmask" BBB permeabilizing actions of leukotrienes. Leukotriene C4 inactive glutathione hydrolase 2 Homo sapiens
2 Sodium fluorescein clearance across HCEC monolayers exposed to leukotriene C4 in the presence of the GGTP inhibitor, acivicin (1 microM), or after in vitro ischemia was increased by 60% and 30%, respectively, suggesting that oxidative stress and loss of GGTP may "unmask" BBB permeabilizing actions of leukotrienes. Leukotriene C4 inactive glutathione hydrolase 2 Homo sapiens