Title : Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells.

Pub. Date : 2001 Jun

PMID : 11447735






3 Functional Relationships(s)
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1 Similarly, but at both doses (1 and 10 microM), raloxifene was able to reduce MMP-2 expression in the cells. Raloxifene Hydrochloride matrix metallopeptidase 2 Homo sapiens
2 However, when used alone (without estradiol) a concentration of 1 microM raloxifene strongly stimulated MMP-2 expression, while at a concentration of 10 microM the effect was not observed. Raloxifene Hydrochloride matrix metallopeptidase 2 Homo sapiens
3 In the case of MMP-9, only trace amounts of this gelatinase were detected, although in contrast to MMP-2, an increase in its expression was noticed at a concentration of 10 microM raloxifene. Raloxifene Hydrochloride matrix metallopeptidase 2 Homo sapiens