Title : Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

Pub. Date : 2001 Sep 28

PMID : 11447225






3 Functional Relationships(s)
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1 Upon exposure of cells to hydrogen peroxide (H(2)O(2)) phosphorylation of p53 was rapidly induced in human fibroblast GM00637, and this phosphorylation occurred on serine 9, serine 15, serine 20, but not on serine 392. Hydrogen Peroxide tumor protein p53 Homo sapiens
2 In addition, H(2)O(2)-induced phosphorylation of p53 was followed by induction of p21, suggesting functional activation of p53. Hydrogen Peroxide tumor protein p53 Homo sapiens
3 In addition, H(2)O(2)-induced phosphorylation of p53 was followed by induction of p21, suggesting functional activation of p53. Hydrogen Peroxide tumor protein p53 Homo sapiens