Pub. Date : 2001 Jul 13
PMID : 11444823
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells. | saikosaponin D | cyclin dependent kinase inhibitor 2B | Homo sapiens |
| 2 | Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other cell cycle related genes were not. | saikosaponin D | cyclin dependent kinase inhibitor 2B | Homo sapiens |
| 3 | Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other cell cycle related genes were not. | saikosaponin D | cyclin dependent kinase inhibitor 2B | Homo sapiens |
| 4 | The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway. | saikosaponin D | cyclin dependent kinase inhibitor 2B | Homo sapiens |
| 5 | The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway. | saikosaponin D | cyclin dependent kinase inhibitor 2B | Homo sapiens |