Title : Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.

Pub. Date : 2001 Jul

PMID : 11442316






2 Functional Relationships(s)
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1 A severe inflammatory response characterized by peritoneal exudation, high peritoneal levels of nitrate/nitrite, and leukocyte infiltration into peritoneal exudate was induced by zymosan administration in iNOS +/+ mice. Nitrates nitric oxide synthase 2, inducible Mus musculus
2 Peritoneal administration of zymosan in the iNOS +/+ mice induced also a significant increase in the plasma levels of nitrite/nitrate and in the levels of peroxynitrite at 18 h after zymosan challenge. Nitrates nitric oxide synthase 2, inducible Mus musculus