Title : Cyclin-dependent kinases and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage.

Pub. Date : 2001 Jul 15

PMID : 11438577






1 Functional Relationships(s)
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1 Previous evidence has shown that the death of embryonic cortical neurons treated with the DNA-damaging agent camptothecin is dependent on the tumor suppressor p53 and cyclin-dependent kinase (CDK) activity and that the inhibition of either pathway alone leads to enhanced and prolonged survival. Camptothecin tumor protein p53 Homo sapiens