Title : Induction of the SAPK activator MIG-6 by the alkylating agent methyl methanesulfonate.

Pub. Date : 2001 Jun

PMID : 11429782






6 Functional Relationships(s)
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1 The alkylating agent methylmethanesulfonate (MMS) activates the c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and the p38 mitogen-activated protein kinase (p38MAPK) pathways via different mechanisms of action. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens
2 The alkylating agent methylmethanesulfonate (MMS) activates the c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and the p38 mitogen-activated protein kinase (p38MAPK) pathways via different mechanisms of action. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens
3 The alkylating agent methylmethanesulfonate (MMS) activates the c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and the p38 mitogen-activated protein kinase (p38MAPK) pathways via different mechanisms of action. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens
4 The alkylating agent methylmethanesulfonate (MMS) activates the c-jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) and the p38 mitogen-activated protein kinase (p38MAPK) pathways via different mechanisms of action. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens
5 The way in which MMS can activate JNK/SAPK has not been elucidated. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens
6 Our results suggest that activation of JNK/SAPKs by MMS may involve the induction of MIG-6. Methyl Methanesulfonate mitogen-activated protein kinase 8 Homo sapiens