Title : Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation.

Pub. Date : 2001 Jun

PMID : 11422444






2 Functional Relationships(s)
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1 The c2-ceramide treatment also increases levels of c-jun, c-fos and p53 mRNA in primary cortical neuron cultures, but this is independent of p38 activation. N-acetylsphingosine tumor protein p53 Homo sapiens
2 Our study further elucidates the time-courses of MAPK cascade modulation, and of c-jun, c-fos and p53 activation during c2-ceramide-induced neuronal apoptosis. N-acetylsphingosine tumor protein p53 Homo sapiens