Pub. Date : 2001 Jun 18
PMID : 11412976
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The energetic and structural results point to the Ile to Val mutation at residue 523 as the key contributor to COX-2 selectivity; unfavorable steric contact between a sulfonamide oxygen and the delta methyl group of Ile523 destabilizes the complex with COX-1. | Sulfonamides | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |