Pub. Date : 2001 Jun
PMID : 11409940
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cytotoxicity in BEC preparations (9/13) was also induced by the supernatants of human liver microsomes and of recombinant human cytochrome P450 (CYP)3A4 preincubated with flucloxacillin (500 mg/L). | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In conclusion, hepatocytes mainly via CYP3A4 activity, generate flucloxacillin metabolite(s) including 5"-hydroxymethylflucloxacillin that may induce cytotoxicity in susceptible BEC. | Floxacillin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |