Pub. Date : 2001 Jun 22
PMID : 11409873
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of this study was to examine the role of MRP1 in the brain distribution of a model organic anion, fluorescein. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 2 | The substrate specificity of MRP1 for fluorescein was initially determined by examining the accumulation of fluorescein in MDCKII MRP1-transfected cells. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 3 | The substrate specificity of MRP1 for fluorescein was initially determined by examining the accumulation of fluorescein in MDCKII MRP1-transfected cells. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 4 | The substrate specificity of MRP1 for fluorescein was initially determined by examining the accumulation of fluorescein in MDCKII MRP1-transfected cells. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 5 | The substrate specificity of MRP1 for fluorescein was initially determined by examining the accumulation of fluorescein in MDCKII MRP1-transfected cells. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 6 | In an in vivo study, after intravenous injection of fluorescein, the fluorescein brain-to-plasma concentration ratio in mrp1 knockout mice was not significantly different than that in wild-type mice. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 7 | In an in vivo study, after intravenous injection of fluorescein, the fluorescein brain-to-plasma concentration ratio in mrp1 knockout mice was not significantly different than that in wild-type mice. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 8 | These findings suggest that fluorescein is a substrate for MRP1. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |
| 9 | Furthermore, the in vivo study also suggests that MRP1 has a limited role in the transport and distribution of fluorescein in the brain. | Fluorescein | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Mus musculus |