Pub. Date : 2001 Jun 1
PMID : 11408043
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The present study examined how the multidrug resistance protein (MRP1), which is an ATP-dependent anionic conjugate transporter, also mediates the transport of reduced glutathione (GSH) and the co-transport of the cationic drug, daunorubicin, with GSH in living GLC4/Adr cells. | Daunorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 2 | We investigated the GSH concentration dependence of the MRP1-mediated ATP-dependent transport of daunorubicin under conditions where the transport of daunorubicin became saturated. | Daunorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 3 | We investigated the GSH concentration dependence of the MRP1-mediated ATP-dependent transport of daunorubicin under conditions where the transport of daunorubicin became saturated. | Daunorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |
| 4 | We were therefore in the situation where GSH acted as an activator: its presence was necessary for the binding and transport of daunorubicin by MRP1. | Daunorubicin | ATP binding cassette subfamily C member 1 | Homo sapiens |