Pub. Date : 2001 Aug 24
PMID : 11402055
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disassociation of MAPK activation and c-Fos expression in F9 embryonic carcinoma cells following retinoic acid-induced endoderm differentiation. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | We found that retinoic acid treatment inhibited the phosphorylation of Elk-1, a target of activated MAPK required for c-Fos transcription. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Thus, we conclude that retinoic acid treatment to induce F9 cell differentiation uncouples Ras/MAPK activation from c-Fos expression by reduction of Elk-1 phosphorylation through a mechanism not involving the activation of phosphoprotein phosphatase 2B. | Tretinoin | Fos proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |