Pub. Date : 2001 Jul
PMID : 11401859
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. | Ionomycin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Dual phosphorylation of p38 MAP kinase and phosphorylation of its substrate activating transcription factor-2 were detected at ionomycin concentrations that prime or activate the PMN oxidase, while dual phosphorylation of p42/44 MAP kinase and phosphorylation of its substrate Elk-1 were elicited at 0.2-2 microM. | Ionomycin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | SB-203580, a p38 MAP kinase antagonist, inhibited ionomycin-induced activation of the oxidase (68 +/- 8%, P < 0.05) and tyrosine phosphorylation of 105- and 72-kDa proteins; conversely, PD-98059, an inhibitor of MAP/extracellular signal-related kinase 1, had no effect. | Ionomycin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Chelation of cytosolic but not extracellular Ca2+ completely inhibited ionomycin activation of p38 MAP kinase, whereas chelation of extracellular Ca2+ abrogated activation of p42/44 MAP kinase. | Ionomycin | mitogen-activated protein kinase 14 | Homo sapiens |