Title : Functional interaction of p53 and BLM DNA helicase in apoptosis.

Pub. Date : 2001 Aug 31

PMID : 11399766






4 Functional Relationships(s)
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1 Certain BLM mutants (C1055S or Delta133-237) that have a reduced ability to localize to the NBs when expressed in normal cells can impair the localization of wild type BLM to NBs and block p53-mediated apoptosis, suggesting a dominant-negative effect. Bromosuccinimide tumor protein p53 Homo sapiens
2 Taken together, our results indicate both a novel mechanism of p53 function by which p53 mediates nuclear trafficking of BLM to NBs and the cooperation of p53 and BLM to induce apoptosis. Bromosuccinimide tumor protein p53 Homo sapiens
3 Taken together, our results indicate both a novel mechanism of p53 function by which p53 mediates nuclear trafficking of BLM to NBs and the cooperation of p53 and BLM to induce apoptosis. Bromosuccinimide tumor protein p53 Homo sapiens
4 Taken together, our results indicate both a novel mechanism of p53 function by which p53 mediates nuclear trafficking of BLM to NBs and the cooperation of p53 and BLM to induce apoptosis. Bromosuccinimide tumor protein p53 Homo sapiens