Pub. Date : 2001 Jun 8
PMID : 11397791
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. | Threonine | nitric oxide synthase 3 | Homo sapiens |
| 2 | In the present study, we assessed whether the agonist-induced (Ca(2+)-dependent, high-output) activation of eNOS is associated with changes in the phosphorylation of Thr(495) in the calmodulin (CaM)-binding domain. | Threonine | nitric oxide synthase 3 | Homo sapiens |
| 3 | eNOS Thr(495) was constitutively phosphorylated in porcine aortic endothelial cells and was rapidly dephosphorylated after bradykinin stimulation. | Threonine | nitric oxide synthase 3 | Homo sapiens |
| 4 | These results suggest that the dual phosphorylation of Ser(1177) and Thr(495) determines the activity of eNOS in agonist-stimulated endothelial cells. | Threonine | nitric oxide synthase 3 | Homo sapiens |