Title : Nociceptor activation and protein extravasation induced by inflammatory mediators in human skin.

Pub. Date : 2001

PMID : 11394922






1 Functional Relationships(s)
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1 Bradykinin (10(-7)M) induced a significant PE, whereas serotonin was effective only at a concentration of 10(-3)M. While serotonin in lower concentrations induced moderate burning pain and an axon reflex flare but no PE, bradykinin provoked PE without pain or axon reflex flare at a concentration of 10(-7)M. Application of histamine similarly evoked PE at lower concentrations as compared to the induction of itch sensation and axon reflex flare. Serotonin kininogen 1 Homo sapiens