Title : Chronic vasopeptidase inhibition restores endothelin-converting enzyme activity and normalizes endothelin levels in salt-induced hypertension.

Pub. Date : 2001 Jun

PMID : 11390717






3 Functional Relationships(s)
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1 Functional endothelin-converting enzyme (ECE) activity was assessed in native segments and after preincubation with omapatrilat. omapatrilat endothelin converting enzyme 1 Rattus norvegicus
2 While omapatrilat in vitro blunted the response to big endothelin-1 (big ET-1) and diminished ECE activity further (P<0.01 vs native segments), chronic treatment with omapatrilat in vivo restored contractions to ET-1 (120+/-6%) and big ET-1 (98+/-9%) in renal arteries, and therefore normalized renovascular ECE activity. omapatrilat endothelin converting enzyme 1 Rattus norvegicus
3 While omapatrilat in vitro blunted the response to big endothelin-1 (big ET-1) and diminished ECE activity further (P<0.01 vs native segments), chronic treatment with omapatrilat in vivo restored contractions to ET-1 (120+/-6%) and big ET-1 (98+/-9%) in renal arteries, and therefore normalized renovascular ECE activity. omapatrilat endothelin converting enzyme 1 Rattus norvegicus